GUT DYSBIOSIS WAS INEVITABLE, BUT TOLERANCE WAS NOT: TEMPORAL RESPONSES OF THE MURINE MICROBIOTA THAT MAINTAIN ITS CAPACITY FOR BUTYRATE PRODUCTION CORRELATE WITH SUSTAINED ANTINOCICEPTION TO CHRONIC MORPHINE

The therapeutic benefits of opioids Bar Trolley are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for drug dependence and addiction.Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-induced gut dysbiosis exacerbates tolera

Megastigmidae comprises more than 200 species in 12 genera.Megastigmus has a worldwide distribution with more than 150 species.Over 80% of these species are recorded from the Australian and Palearctic region, with a few from Afrotropical and Oriental regions, but none from the Neotropical region.We describe a new species of Megastigmus obtained fro

Abstract The internal microenvironment of a living cell is heterogeneous and comprises a multitude of organelles with distinct biochemistry.Amongst them are biomolecular condensates, which are membrane-less, phase-separated compartments enriched in system-specific proteins and nucleic acids.The heterogeneity of the cell engenders the presence of mu

Background: Hyperhidrosis is unnecessary sweating afar the body needs for cooling down the body temperature.It affects nearly 2-3% of the population with equal gender predominance.Both medical and surgical interventions have been utilized to treat primary hyperhidrosis.Over 80% of patients with palmar hyperhidrosis (PH) also experience plantar hype

Most psychiatric disorders are associated with subtle alterations in brain function and are subject to large inter-individual differences.Typically the diagnosis of these disorders requires time-consuming behavioral assessments administered by a multi-disciplinary team with extensive experience.Whilst the application of machine learning classificat